Red Mage introduced this campaign to my world: The Awesome Object campaign. Each member of the party gets a fantastic artifact, and The Man, (or original owner) wants it back. Anyway, it would be a cool way to give each player a completely different role, and give a fantastic power to an otherwise mundane person.
The Portal Gun
Master Chief Suit
That Illusion Disguise Thing From That Bad Movie
The Healing Gun The Medic Uses in TF2
And So On