So, the 'best show on TV' award belongs to Venture Bros. or The amazing Screw-On Head. If Screw-On Head has another episode, I'll give it my vote.
There are a few similarities between the two shows:
Both are cartoons.
Both are parodies of the 'super' genre.
Both have a relatively low budget.
Both are on non-major channels (Sci-fi and Cartoon network, respectively).
What does this tell us? Shows don't need money to be good, and there's nothing about the 'major' channels that makes them better than the fringe channels. All a show needs is talented people putting their best into a product.