I know I'm late to the party, but The Wire may be the best TV show of all time. There are different ways you could measure that sort of thing, so I'll say it's the best show on average, as every piece of it is so perfectly executed, and there's never a bad episode.
Other shows, like The Simpsons, and All In The Family, have been more influential, thanks to their larger audiences, but The Wire pushes boundaries further than most any other show. Unlike those other shows, The Wire quits when it's still on top.
It's interesting how the media has agreed to depict police work and the crime system in an identical idealized picture. The Wire annihilates many of the clichès that plague our American view of the world of crime.
It appears that the creator of The Wire is on the same boat as Jon Stewart in blaming the media for ignoring stories of any complexity or controversy.